Debuting in the fall of 2000 on Fox, the James Cameron-directed series Dark Angel is a sort-of Buffy the Vampire Slayer meets The Pretender in 2020 post-nuclear Seattle, following the story of a genetically-enhanced young woman named Max (played by Jessica Alba) who escaped years ago with several others from a secret military institution called Manticore.
Ten years later, Max now lives in Seattle, where she works as a bike messenger and hangs out with a handful of friends including her lesbian best friend Original Cindy (Valerie Rae Miller), and her love interest Logan Cale (Michael Weatherly), a wheelchair-bound vigilante crusading for world peace. When she's not fighting/evading the evil folks from Manticore or pretending she's not attracted to Logan, Max is generally chatting with her friends at work or at the local bar.
Dark Angel introduces Original Cindy's sexuality early in the pilot episode with the following exchange between her and Max at work as they're observing their friend Sketchy with his girlfriend:
Later in the same episode, when Sketchy asks Max's help in preventing his girlfriend from finding out he's cheating on her, Original Cindy's sexuality is referenced again: