Hmmm...nice pics for casting, but here's how I see it if I were lucky enough to cast this film:

Yorick--Ryan Gosling

Dr. Mann--Lynn Chen (Saving Face)

Agent 355--Sonya Sohn (Kima from The Wire)

Hero--Piper Perabo

Agent 355 - Rose Rollins

"Has anyone else been following this comic series?"

No, but you make it sound like I better.

"a movie where 99.9 percent of the on-screen humans are of the female variety"

okay, I'm sold.

thank you jen from p!

Along with "Gotham Central", that is one of my favorite comic books of all times! They could cast Jake Gyllenhaal as Yorick and Frances McDormand as Dr. Mann. Well, I guess that's why I'm not a casting director...

Ohh hell yeah! I waited quite some time for Y to have a big chance!

I feel in love with this comic... I started reading it after Runaways was released. Brian K Vaighan, the author, is one of the nicest dude ever. I sent and e-mail, he answered my every single "about your lesbian characters..." question.

Strange thing, I never thought about a casting for it, but wouldn't be bad if they had new faces for some os the main characters.

I love this comic. Brian K. Vaughn is probably my favorite comic writer out there right now (Y, Runaways, Ex Machina, Buffy!!!) I'm really worried it will be butchered when it hits the big screen, See: X-Men 3. I'll still be seeing it opening night, mind you, regardless.

When the rumors of the movie first came out Topher Grace was mentioned for the lead and I think he has that nerdy/cool/average thing that would work for Yorick.

Gina Torres for 355 maybe? Lucy Lu for Dr.Mann? she is Hollywood's token asian afterall.

With a cast that full of women there is bound to be a celebrity crush for everyone, I just hope it's made half-decently.

I'm incredibly excited about the prospect of this movie being made. I adore the comic.

As for casting, I'd go with:

Yorrick = Ryan Reynolds, whenever I picture a live action version o f the character the image that always comes to mind is Reynolds.

Agent 355 = Traci Thoms, my conviction that Traci Thoms would make a wonderful, totally badass 355 has only been strengthen since Grindhouse: Death Proof, which she pwned. Although I'll admit, I like the suggestion of Rose Rollins. She's a bit more of a straight up hottie than I pictured 355, but Rose can certainly bring the badass and looks good with a gun.

Dr. Mann = Maggie Q, yeah okay that's mostly because I like looking at Maggie Q and I'd get to look at her for a long time in a Y: The Last Man movie, but I think she'd also be alright in the role. Did I mention I like to look at Maggie Q.

Sandra Oh, is also an inspired choice. Sandra delivering "Y"ish dialogue would be a thing of beauty, also we already know that she can play a doctor, lol

Hero = Jennifer Carpenter, I think she's practically perfect for it. Check out an episode of Dexter and tell me if you couldn't see her in the role. Also, I think she looks remarkably like comic Hero.

There's no way I can even begin to say how excited I am about this. I love Y! It's in my top five of comic favs for life. Its definitely one of the best written comics ever. I hope they don't ruin it...like they do with so many comic books. It's awesome...practically writes itself. One man in all the world, a kick ass monkey, lesbians, male-impersonating prostitutes...what more can you ask for, lol? Oh, love that cover from "girl on girl" its beautifully rendered. 355/Mann love extra awesomeness. Just read it! Please, excuse my fangirl moment.

Yorrick - Toper Grace (near perfect), Justin Long, Ryan Reynolds.

355 - Gina Torres, Sonya Sohn, Rose Rollins.

Mann - Sandra Oh, Joan Chen (in a perfect world), Maggie Q.

Ampersand - That monkey from outbreak.

I am what I am. Love me or hate me. Just consider me.

...like a number of fans, I'm worried that they could easily mess this up as a film. However, I will certainly follow it with interest.

I'd obviously recommend the comic series to anyone here for a number of reasons beyond the legion of ladies involved. It's very intelligent and works to keep you off balance and it's characters just slightly outside the comfort zone you might enjoy. You find yourself sympathising with individuals who's actions you deplore and angry with those you want to love. It elicits a complex emotional response: volume 2 of the graphic novel is one of the hardest things I've ever read and had me tearing through the pages utterly absorbed and desperate for some sort of cosy resolution that would put things right. It didn't come and I've not actually been able to read it again.

The character of Hero left me utterly conflicted because the clever writing in the first volume made me identify so heavily with her and completely floored me when it actually introduced her to the plot. I think she would be an exceptionally challenging and difficult part to play. I feel she is brilliant and terrifying in a very personal way.

The series is extremely topical and astute; it challenges the neat pigeonholes into which society places people caught up in the current political situation and our attitudes and assumptions about morality, ideology and their underpinnings.

ampersand....i forgot. 

 I think the choice made to use the monkey from outbreak is good...but I'm thinking more along the lines of the monkey from Raiders of the Lost Ark.  Did you see his death scene after he ate that fig?  The tears....right down my face.  Oscar worthy.

You can forget that monkey from Friends.  He's a total hack.

I've been a huge fan of Y The Last man for a long time.

I could not be more excited about a movie and I really really hope this isn't going to be only rumours and never come to anything.

I'm hoping for a great director too, any ideas?

It needs a brilliant cinematographor, someone with a real vision of the details within the world of Y.

Yes, I agree that a serial on HBO or something would be MUCH better.  I mean, it's already in digestable form and pretty much storybooked.   I do love that Ellsworth is scripting it, though.  I could imagine some awful hacks turning it from the dystopian gender examination that it is, back into the stupid fantasy that most men think it's supposed to be.

That said:

Michelle Krusiec or Vivian Wu- Dr. Mann

Ryan Gosling- Yorick

Taraji P Henson- 355

Claire Forlani or Kate Beckinsdale- Hero

Elizabeth Banks or Kate Bosworth - Beth (the flight attendant)

I've just finished reading "Y: The Last Man", and want to quickly gush about it - it's the best comic ever! Definitely my favourite. I'd recommend it to anyone. Especially if you're not really into comics.

Anyhow, it seems word is that the plan of action for a "Y" film is for it to be in a trilogy, which makes sense to me - there's no way all the material would fit into a standard feaure-length film, as people have said. Not without loads of stuff getting left out, anyway - which would definitely suck.

I've no idea about who should be cast, I'm still putting thought into that one, but the rumour is that Shia LaBeouf will play Yorick. Hmm, I'm not sure how well that would work...

Whatever happens, I hope the film is a success and I look forward to hearing more about it (I read somewhere they were hoping for a 2009 release?). It will be interesting to see the storylines play out in the film format.